In today’s world, many of us are struggling with being overworked, undernourished, and constantly stressed. Maintaining a healthy body weight is yet another challenge to stack on top of this, and for many, seems like an impossible task. As obesity rates rise and we are incessantly marketed a plethora of diets and weight loss solutions, it is difficult to navigate the path to better health.

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In Episode #260, I’m joined by Dr Stephan Guyenet, a highly respected researcher and expert in the field of hunger, weight loss, and obesity. Together, we delve into the science behind eating behaviours, obesity, and the reasons why losing weight and keeping it off can be so challenging.

In this episode, we explore the widespread issue of obesity and how the brain plays a crucial role in our eating behaviours. Dr Guyenet explains the biological and psychological factors that contribute to weight gain, and the challenges that people face when trying to lose weight and keep it off. We delve into the different types of eating, including homeostatic and nonhomeostatic eating, and how they influence our consumption of calories.

TIMESTAMPS:

00:00 Intro
01:36 From neurodegenerative disease to obesity neuroscience
10:38 The holiday weight gain
14:37 The problem with excess fat
26:06 'Personal fat threshold' and diabetes
31:26 Main drivers of type 2 diabetes
38:55 The role of the hypothalamus in weight gain
47:29 Homeostatic vs. nonhomeostatic eating
56:50 Genetics and the obesity epidemic
1:00:21 Models of obesity: carbohydrateinsulin vs. energy balance
1:10:25 The brain and obesity
1:19:39 The proteinleverage hypothesis
1:24:19 Carbohydrates, fat, and the Mediterranean diet
1:30:22 The weight loss puzzle: low carb vs. low fat diet
1:38:36 Foods that promote satiety on fewer calories
1:43:19 GLP1 agonists
1:55:17 Is weight loss largely dependent on exercise?
1:58:51 Physical activity vs sedentary lifestyle
2:02:00 Mental health and sleep
2:05:20 Expert advice on how to stop overeating
2:07:05 Outro

Dr Guyenet also sheds light on the importance of controlling our food environment and the reasons behind excess calorie consumption. We discuss various strategies for weight loss, from the impact of diet and exercise to Semaglutide and GLP1 agonists. Throughout our conversation, Dr Guyenet shares practical advice and evidencebased insights to help listeners better understand the complexities of weight management and make informed choices about their health.

As obesity and weight management continue to be such prevalent issues, I hope this conversation with Dr Guyenet has provided valuable insights and practical strategies that you can apply to your own life or share with your loved ones. Thank you for joining me on *The Proof*’s journey towards better health and wellbeing for ourselves and our broader communities.

Connect with Dr Stephan Guyenet:

Twitter:   / sguyenet  
Website: https://www.stephanguyenet.com/
Book: https://www.stephanguyenet.com/thehun...
Red Pen Reviews: https://www.redpenreviews.org/

If you have any additional questions you would like answered in the future, let me know in the comments.

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Enjoy, friends.

Simon

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