In Episode 237, I’m joined by Dr Valter Longo for an exploration of protein, cancer, the fastingmimicking diet, IGF1, and mTOR.

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Regular listeners of The Proof will know that protein is frequently featured in episodes. As an area of nutrition where the scientific community is split, I am interested in digging into the specifics of each viewpoint – and most importantly, the evidence behind each one. Highly requested guest, Dr Valter Longo, returns to the show today to share his position on this contentious topic.

Dr Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the USC Leonard David School of Gerontology, one of the leading centres for research on aging and agerelated disease. Dr Longo is also the Director of the Longevity and Cancer Program at the IFOM Institute of Molecular Oncology in Milan, Italy. His studies focus on the fundamental mechanisms of aging in simple organisms and mice, and on how these mechanisms can be translated to humans. With extensive education and a prominent career, Dr Longo brings an incredibly interesting perspective to today’s conversation.

In this episode, we zoom in on terms that have become buzzwords in the protein space, including IGF1 and mTOR. We discuss protein requirements for different ages, muscle tissue importance, benefits of protein consumption, and potential risks. We also cover the fastingmimicking diet for both regular folks and as an adjunct cancer treatment.

Specifically, we discuss:

0:00 intro
2:58 Ideal diets for longevity
9:15 Important Pathways for aging
16:24 IGF1 Elevation
19:46 Acute vs Chronic elevation of IGF1
25:11 Danger of Protein Over Consumption
32:52 Impact of exercise on IGF1
38:35 Muscle Mass and Longevity
41:59 Study on High Protein Later in Life
48:03 How to get IGF1 tested
49:54 Low IGF1 & Cognitive Decline
53:00 Resistance to IGF1
54:38 Mendelian Randomization Studies
59:21 Fasting Mimicking Diet
1:16:03 Fasting and Cancer
1:27:51 Ketogenic Diet & Cancer
1:32:15 Outro

I appreciate having Dr Longo on the show today and hearing yet another perspective on protein, plus much more interesting research and insights. I hope you found this conversation interesting and informative as part of The Proof's exploration on protein. If you're feeling confused or overwhelmed by the amount of information (and partially conflicting stances) The Proof has covered lately, don't fret – I will be releasing a recap and evaluation of this learning soon.
Make sure to follow the Proof on Instagram:
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Connect with Dr Valter Longo:
• Instagram:   / prof_valterlongo  
• Facebook:   / profvalterlongo  
• Website: https://www.valterlongo.com/
• His book, The Longevity Diet: https://www.valterlongo.com/thelonge...
• Dr Longo’s previous appearance on The Proof Episode 106: https://theproof.com/slowageingfigh...

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Enjoy, friends.

Simon

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