When it comes to taking control of our health, embracing a comprehensive view and longterm focus is paramount. Looking towards our future, and reflecting on our family history, neurodegenerative diseases can be a significant cause for concern for many of us. In Episode #263, the exceptional Drs Ayesha and Dean Sherzai return to The Proof, delving deeper into the complex world of neurodegenerative diseases.

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Dr Dean Sherzai is a behavioural neurologist and neuroscientist who has dedicated his life to behavioural change models at the community and population levels. Dr Ayesha Sherzai is a distinguished vascular neurologist and research scientist focused on empowering her patients and their communities. Drs Dean and Ayesha Sherzai are the authors of two bestselling books, The Alzheimer's Solution (2017, HarperCollins) and The 30Day Alzheimer's Solution (2021, HarperCollins). They are currently leading the largest communitybased brain health initiative in the country.

Specifically, we discuss:
00:00 Intro
04:11 Drs. Ayesha and Dean play True or False
05:47 Is amyloid plaque the primary cause of Alzheimer's?
07:11 Whole grains, gluten, and brain health
14:11 Artificial intelligence for Alzheimer's disease
17:47 Drs. Ayesha and Dean on Melbourne
20:35 Is olive oil good for brain health?
24:56 What's the beef with red meat?
35:44 Keeping the brain healthy with omega 3 fatty acids
48:58 APOE4 and omega 3 supplementation
55:12 Cognitive changes in midlife
59:35 Reaction to Dr. Michael Klapper's Uturn on omega 3 supplementation
1:02:52 Facts on choline
1:08:30 Understanding neurodegenerative diseases
1:18:24 Inheriting frontotemporal dementia: what are your chances?
1:21:04 Lifestyle vs. genetics: debunking myths about dementia risk
1:28:36 Healthy habits for a healthy brain
1:37:18 Close relationships & cognitive resilience prevent dementia
1:50:17 Understanding amyloid plaques and Alzheimer's progression
2:00:10 Amyloid hypothesis under scrutiny
2:06:52 Biomarkers and cuttingedge techniques for Alzheimer's detection
2:21:04 How to prevent cognitive decline
2:24:00 Homocysteine, CRISPR, and the future of personalized medicine
2:29:54 Huntington's disease and Parkinson's disease
2:44:47 Depression and anxiety
2:50:44 Chronic inflammatory demyelinating polyneuropathy (CIDP) & GuillainBarré
2:56:28 Unpacking Multiple Sclerosis (MS)
3:06:58 Outro

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Past episodes: https://theproof.com/tag/ayeshasherzai/

If you have any additional questions you would like answered in the future, let me know in the comments.

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Enjoy, friends.

Simon

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