Patient RJ by Jake Rattan, Friend 1 by Matt Hernandez, Food Enjoyer by Lexi Richmond, PA/Friend 4 by Luke Menzies
Mark Rober Hot Ones:    • Mark Rober Gives Up on Science While ...  
Peer Review: Dr Araceli Morga Vera, Dr Yue Wu, Dr Katherine Johns
Spanish translation and dub: Cenzontle Voices Inc, CDMX
Portugese translation and dub: George Frederico
Music by @Lifeformed ► https://lifeformed.bandcamp.com

Indepth (podcast) channel @HemeReview
Secret Channel @BigEmus

Medicine ►    • Medicine  

There's a secret version of this video in 8k:    • A Man Drank 1 Bottle Throat Numbing S...   the music levels were out of whack on that one so I elected to publish this one instead

0:00 Throat Numbing Spray Label
0:14 A Man Swallowed 1 Bottle Throat Numbing Spray While Eating Spicy Food
2:00 haha spray go glug glug
3:29 The emergency room where we are now
4:10 Cyanosis and oxygen saturation
5:05 Arterial blood gas vs oxygen saturation
5:58 ...but something's wrong
6:38 This brings us back to the spray...
7:16 I promise you that stuff you learned in high school chemistry was worth it because it applies here
10:07 What does the throat numbing spray have to do with this?
12:10 ONOO (Biochemical breakdown)
14:49 Throat numbing spray misuse isn't new
15:52 When you misuse the antidote and it becomes a poison itself

Some images by Getty Images

These cases are patients who I, or my colleagues have seen. They are deidentified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:
Benzocaineinduced Methemoglobinemia. https://www.ncbi.nlm.nih.gov/pmc/arti...

Reported Adverse Event Cases of Methemoglobinemia Associated With Benzocaine Products. https://jamanetwork.com/journals/jama...

Safety Information on BenzocaineContaining Products. https://www.fda.gov/drugs/postmarket...

Benzocaine. https://www.cureus.com/articles/68795...

Continuous Methylene Blue Infusions for Treating Recurrent Methemoglobinemia. https://toxandhound.com/toxhound/refr...

Methemoglobinemia https://emcrit.org/ibcc/methemoglobin...

Pulse Oximetry https://emcrit.org/pulmcrit/pulseoxi...

Characterization of the methemoglobin forming metabolites of benzocaine and lidocaine. https://www.tandfonline.com/doi/abs/1...

Identification of NHydroxyparaaminobenzoic acid in a cyanotic child after benzocaine exposure. https://pubmed.ncbi.nlm.nih.gov/25211...

A mitochondrial superoxide theory for oxidative stress diseases and aging. https://www.ncbi.nlm.nih.gov/pmc/arti...

4.2 Oxygen Binding: https://chem.libretexts.org/Bookshelv...

Benzocaine Label without Methemoglobinemia warning: https://fda.report/DailyMed/29890aa7...

Acute Phenol Poisoning: https://www.jstor.org/stable/27720955

Goldfrank's Toxicologic Emergencies 11th Edition Text

Methemoglobinemia. UpToDate. Accessed 01 Feb 2023.