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Patient JC by Chad Collins, PA Tristyn Smith, Special Thanks to Jena Marx

Music by @Lifeformed ► https://lifeformed.bandcamp.com
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Timestamps:

0:00 A Bodybuilder Mistook An Aphrodisiac for PreWorkout Supplement
0:22 JC was getting ready for a show
0:55 A wild supplement appears
1:35 Hey IRS we doing research ‍ and development
1:50 Good ☁ powder
2:16 haha preworkout go glug glug
3:13 The emergency room where we are now
4:07 How does do all of these??
4:50 Rumors of this toxicity... are not exaggerated at all. It's not good.
5:50 Neuro transmitters gotta go fast
6:48 Inside you(r autonomic nervous system) are 2 wolves (just kidding, they're more nervous systems)
7:27 What happens here?
8:16 Alpha vs beta (not alpha male vs beta male)
9:11 In the central nervous system
9:47 Feedback mechanism (in normal function)
10:51 The CEO of systemic... response to adrenergic agents
11:35 Multiple reports in existence
12:02 "Just pull it out of his body bro"
12:23 An Antidote But How Did We Find It?
14:45 Yea lets not use that here, but we could use something else
15:15 It takes 5 half lives to reach steady state, but Half Life 3 still isn't here

I don't think anyone reads anything that's written here. But here's for the metadata: this video is explicitly about adrenergic receptors. More specifically, the Alpha subtype, and even more specifically, Alpha 2 Adrenergic Receptors. This thing throws a massive curveball to learners in all medical disciplines because Alpha 2 agonism / antagonism are opposite of Alpha 1. The topic of these receptors can be a few weeks long in a Pharm course in Medical and Pharmacy schools, and that course would be dedicated specifically to cardiac pharmacology, so this is as much I can cover in an 18 minute video. There might be people who will go "nooooo u cant just say that about my tree bark supplement" but the point is and has always been to teach about the pharmacology, its mechanism and how the setting of excess changes the pharmacokinetics the agent serves as a means for me to teach that because it has that activity. If it didn't have that activity, I'd talk about something else that does in this setting. It's a fascinating molecule, like all natural products. If you don't need to ingest it, don't ingest it, but I trust you are well in your best capacity to make decisions for yourself.

These cases are patients who I, or my colleagues have seen. They are deidentified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet.

References:

Acute neurotoxicity after yohimbine ingestion by a bodybuilder. https://pubmed.ncbi.nlm.nih.gov/19640...

Yohimbine: a clinical review. https://pubmed.ncbi.nlm.nih.gov/11744...

Alpha2 Adrenoreceptor Antagonist Yohimbine Potentiates Consolidation of Conditioned Fear. https://academic.oup.com/ijnp/article...

Adrenergic receptors: structure and function. https://pubmed.ncbi.nlm.nih.gov/2164898

Biopharmaceutics and metabolism of yohimbine in humans. https://pubmed.ncbi.nlm.nih.gov/10494...

Yohimbe bark extract. https://ntp.niehs.nih.gov/sites/defau...

Yohimbine or NOhimbine? A Potentially Fatal OvertheCounter Supplement. https://www.vumc.org/poisoncontrol/t...

[PREPRINT] Xylazine is an agonist at kappa opioid receptors and exhibits sexspecific responses to naloxone administration. https://www.biorxiv.org/content/10.11...

Xylazine, an Emerging Adulterant. https://www.acep.org/talem/newsroom/o...

Yohimbine. https://pubmed.ncbi.nlm.nih.gov/4037464/