Kevin A. Murach, Ph.D., completed a master’s degree in Exercise Physiology at James Madison University in Harrisonburg, Virginia, then earned his Ph.D. in Human Bioenergetics from the Ball State Human Performance Laboratory in Muncie, Indiana. After Ball State, Dr. Murach spent six years as a postdoctoral fellow/scholar studying muscle stem cells at the University of Kentucky Center for Muscle Biology in Lexington under the guidance of Drs. Charlotte Peterson and John McCarthy. He now is an Assistant Professor at the University of Arkansas. His current research uses human muscle samples, primary cell culture and genetically modified mouse models to understand the molecular cues that drive exercise adaptations and aging, and the interaction between the two.

In this episode we discuss:
Why Yamanaka factors matter for muscle adaptation and age reversal.
How does exercise improve longevity?
What is DNA methylation and how does it affect muscle?
How to train for overall health and aging.

Chapters:
00:00:00 Introduction
00:05:49 Aging Muscle and Exercise
00:11:17 Decline in Muscle Mass with Aging and Physical Activity
00:16:12 Muscle Biopsy and Molecular Reprogramming
00:22:21 Epigenetics and Gene Expression
00:32:57 Yamanaka Factors and Exercise
00:38:47 Transcription Factors and Exercise
00:44:20 Exercise and Gene Expression
00:49:46 Mick Protein Levels in Muscle
00:54:56 The Epigenetic Profile and Aging
01:00:40 Methylation Aging and Functional Changes
01:05:46 DNA Methylation and Exercise Training
01:16:15 Balancing Strength and Endurance in Exercise
01:21:19 The Importance of Endurance and Resistance Training

This episode is brought to you by Timeline Nutrition, AquaTru, PaleoValley, Inside Tracker, 1stPhorm

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