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A snake, especially, a cobra is a tasty meal for the mongoose. So, it fights to kill, while the cobra fights to defend itself. When the cobra strikes, the mongoose's lightning speed helps it dodge the strikes, causing the cobra to miss repeatedly.

But what if the cobra succeeds in striking?

Toxins in the snake's venom attach to the acetylcholine receptors, blocking communication between nerves and muscles, ultimately causing death. However, in mongoose, these receptors are mutated or shaped differently. The toxin cannot attach to the receptors, making venom ineffective. Eventually, when the cobra gets exhausted, the mongoose snaps with its sharp teeth, killing the cobra and winning the battle.

Mostly, between the cobra and mongoose, mongoose wins. However, if the snake is a viper or Boa constrictor, then the mongoose can be killed.