In this YouTubeexclusive episode, I’m joined by Professor Nir Barzilai to examine the possibility of a drug that could slow aging.

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Dr Barzilai joins me in this conversation for an exploration of a potential drug intervention for aging: the diabetes medication metformin. Is it possible to comprehensively target the biomarkers of aging? How much benefit can a medical intervention have over lifestyle factors? Where is the science now, and where is it heading? We discuss these questions and many more in this conversation.

Dr Nir Barzilai is a geroscientist, chaired Professor of Medicine and Genetics, and principal investigator of the Einstein Nathan Shock Center and the Glenn Center in the Biology of Aging Research. His paradigmchanging studies focus on families of centenarians, providing genetic and biological insights on the protection against aging. Dr Barzilai has authored over 300 peerreviewed papers and received a number of prestigious awards, and is now leading the TAME (Targeting Aging with Metformin) study, among other research.

You will learn about the potential functions of metformin as a treatment for aging from a pioneer in the field. We discuss how we can slow aging and increase health span, including the effect metformin could have on a population level. We also cover longevity genes, the significance of growth hormones, and much more.

Specifically, we discuss:

01:54 Can we slow down or even reverse aging?
05:36 The secret of centenarians
12:18 Can genes be the key to unlocking longevity?
15:53 What safe interventions look like
26:07 Treating aging vs treating diseases
30:24 TAME Targeting Aging with Metformin
52:04 Effective indicators of health and disease risk
54:44 Can Metformin protect against cognitive decline?
1:06:40 Metformin and exercise
1:13:46 How promising is Metformin?
1:22:50 Expectations for TAME trial
1:25:24 Tips for achieving good health and targeting hallmarks of aging
1:31:52 Protein and aging
1:35:03 Can supplements combat aging?
1:38:10 Outro

On The Proof, we often cover lifestyle changes people can implement to improve their health – and this was a very interesting opportunity to examine where the drugbased science is headed for aging. Aging is an intriguing field of study, and I’m glad to have had Dr Barzilai on the show today to offer his insight into the TAME Trial and more information about metformin.

To connect with Dr Nir Barzilai, you can find him on Twitter:   / nirbarzilaimd  . Read his book, Age Later: Health Span, Life Span, and the New Science of Longevity https://www.amazon.com/AgeLaterHeal..., to learn more.

Connect with Dr Nir Barzilai:

Twitter:   / nirbarzilaimd  
Book, Age Later: https://www.amazon.com/AgeLaterHeal...
TAME Trial: https://www.afar.org/tametrial](https://www.afar.org/tametrial

If you have any additional questions you would like answered in the future, let me know in the comments.

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Enjoy, friends.

Simon
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