The newest patient at Princeton–Plainsboro Teaching Hospital is influenced by selfdestruction. Is wanting to be pain free a sign of mental illness? Meanwhile, Foreman questions Thirteen on continuously trying to shut out everyone around her.

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From Season 5 Episode 12 ''Painless'': At Cameron's (Jennifer Morrison) urging, the team takes the case of a suicidal man who suffers from excruciating chronic painpain that mirrors House's (Hugh Laurie). Meanwhile, Cuddy (Lisa Edelstein) discovers that caring for her newly adopted baby leaves her little time to run the hospital.

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