The brain is one of the most astonishing, efficient, and intricate parts of the human body, and it is amazing what it can do unconsciously. It’s only when it stops functioning properly, such as in people who have been diagnosed with schizophrenia, that we can get a true appreciation of the ease at which simple decisions are made by our brains. Dr James Kesby is a behavioural neuroscientist who has focused his studies on the brain circuits that underlie psychotic disorders and addiction. As an Amplify Fellow at the Queensland Brain Institute at The University of Queensland, he is particularly interested in how the brain computes uncertain situations in order to make an optimal choice. His work spans circuitbased approaches in rodents, to psychological studies in people (including those with psychosis). This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx