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Derek is a fitness educator & the entrepreneur behind More Plates More Dates & an expert in molecules commonly used & misused by bodybuilders & athletes. This conversation explores various compounds like growth hormone, testosterone, androgens, SARMs, estrogen, finasteride, peptides, & much more. Derek walks through how these molecules are used by athletes to gain an edge while also exploring their impact on disease risk, hair loss, fertility, & more. This conversation aims to provide insights into whether these compounds are uniformly harmful or if there are broader implications that could benefit the general population.

We discuss:
0:00:00Intro
0:00:47Derek’s experimentation with anabolic steroids at a young age
0:10:28Acquiring steroids from underground labs & the potential longterm fertility concerns early in his bodybuilding career
0:15:56Backstory on More Plates, More Dates & Derek’s unique ability to blend scientific knowledge with personal observation
0:21:23Growth hormone—from extreme usecases to the more typical—& the misconception that it’s the “elixir of life”
0:29:34Growth hormone 101: definition, where it comes from, & the challenges of measuring it
0:41:43Does exogenous growth hormone compromise one’s ability to make endogenous growth hormone?
0:43:51Use of growth hormone in restoration of tissue during periods of healing
0:51:45Growth hormonereleasing peptides to increase endogenous GH: various peptides, risks, benefits & comparison to exogenous growth hormone
1:07:12Role of growth hormone in building muscle & burning fat, as well as its effects on sleep & daytime lethargy
1:15:00Evolution of drug use in the sport of bodybuilding
1:27:01What explains the protruding abdomens on some bodybuilders & athletes?
1:33:20Death of bodybuilders
1:42:15Complex interplay of hormones, & the conversion of testosterone into metabolites like DHT & estrogen
1:52:23Postfinasteride syndrome & how Derek successfully treated his hair loss
2:07:55Testosterone replacement therapy: compelling usecases, side effects, & optimal dosing schedules
2:28:56Aromatase inhibitors to suppress estrogen, & the misconceptions around estrogen in men
2:34:38Other hormones beyond testosterone for male sex hormone replacement
2:38:45History of anabolic compounds, & the differing effects of various anabolic testosterone derivatives & related drugs
2:44:24Use of SARMs by bodybuilders
2:51:53Anabolic steroid & testosterone regimens of professional bodybuilders & the downstream consequences
3:01:20Challenge of accurate hormone testing in the presence of anabolic steroids & supplements
3:04:10Use of Clomid, hCG, & enclomiphene
3:18:37Concerns about fertility: comparing the use of testosterone & hCG
3:31:33Use of BPC157 peptide for healing injuries


About:

The Peter Attia Drive is a deepdive podcast focusing on maximizing longevity, & all that goes into that from physical to cognitive to emotional health. With over 70 million episodes downloaded, it features topics including exercise, nutritional biochemistry, cardiovascular disease, Alzheimer’s disease, cancer, mental health, & much more.

Peter Attia is the founder of Early Medical, a medical practice that applies the principles of Medicine 3.0 to patients with the goal of lengthening their lifespan & simultaneously improving their healthspan.

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