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Why is rabies so hard for the immune system to kill?

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Phy The Neutrophil

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Happy Halloween. I'm talking about the most nightmareinducing virus: rabies lyssavirus. But if you came here for the gory details, this might not be the video for you. Instead, I want to have a look at why this virus is so hard to overcome, as it sits at an unbelievable 100% mortality rate once symptoms show. Are our immune systems slacking? Or has rabies evolved some truly terrifying means of evasion?

Sources:

General Rabies Biology:
Davis et. al (2015) Everything you always wanted to know about Rabies Virus (but were too afraid to ask)

Zhang et. al (2022) Regulation of innate immune responses by rabies virus

Dynein:
Toba et. al (2006) Overlapping handoverhand mechanism of single molecular motility of cytoplasmic dynein

Medmonk's Dynein Video:    • Dynein Animation  

Rabies Vaccine:
WHO Preventing Rabies by Vaccination

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All drawn cellrelated assets were done by Toxo.

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Music:
"Onion Capers" Kevin MacLeod (incompetech.com)
Licensed under Creative Commons: By Attribution 4.0 License
http://creativecommons.org/licenses/b...

posted by avodate5