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Firstly, people with Arachnophobia i.e. fear of spiders will be one happy lot.
Secondly, museums will open up, showcasing the strength as well as the engineering marvel of a spider web.
Thirdly, Spiders are ferocious predators of pests. Without any Spiders, these pests will eat away our crops. Humanity will probably face a famine like situation.
Fourthly, spider's venom as well as spider's web are believed to have a number of medicinal properties. With no Spiders, medical fraternity will definitely suffer a big loss.
Fifthly, Spiderman will probably lose his super powers, super heroes will be in for a shock.
Lastly, with no more spiders, directors of scary Hollywood movies may run out of new ideas to scare people.