Find out more about real antiaging drugs in my book, Ageless: The new science of getting older without getting old https://ageless.link/
Or watch more longevity videos in my playlist: • Aging
Chapters
00:00 Introduction
00:46 Rapamycin
02:34 Senolytics
04:49 Metformin
06:18 Taurine
07:24 Statins
09:54 Conclusion
Sources and further reading
If you want to know more about rapamycin, this @mattkaeberlein4086 video is a longer introduction to the science behind it • Rapamycin is the gold standard for lo...
And, if you want to know much more about metformin (and a bunch of other cool longevity science), you might enjoy Nir Barzilai’s interview with @TheProofWithSimonHill • Slow Aging with a Pill? | Nir Barzila...
Rapamycin
Review of the evidence for rapamycin, rapalogues and other mTOR inhibitors in humans https://www.sciencedirect.com/science...
Phase 2b and Phase 3 trials of rapamycinlike drugs for improving immunity in older people https://www.thelancet.com/journals/la...
Senolytics
2018 paper giving D+Q to old mice https://www.nature.com/articles/s4159...
A great overview of the dozens of companies currently working on senolytics https://www.nature.com/articles/s4158...
Metformin
Study showing people with diabetes taking metformin outlived ‘healthy’ controls https://dompubs.onlinelibrary.wiley....
Taurine
More information and links in my Twitter thread on the results / 1667075657874939907
The paper (sadly paywalled) https://www.science.org/doi/10.1126/s...
Statins
Effect of statins on allcause mortality in adults: a systematic review and metaanalysis https://www.mdpi.com/20770383/11/19/...
General
A recent paper from the Interventions Testing Program (ITP), with an overview of its successes so far: ‘Six compounds have thus far produced significant extension of life span in ITP studies in 1 or both sexes: rapamycin, 17αestradiol (17aE2), nordihydroguaiaretic acid (NDGA), Protandim, glycine, and acarbose.’ (This paper adds Canagliflozin to the list.) https://www.ncbi.nlm.nih.gov/pmc/arti...
Calculations for risk of diseases with age can be found at https://github.com/ajsteele/ageless
Oh and btw, I’m British so I normally spell it ‘ageing’ just in case anyone’s searching for ‘antiageing’. Some people call this field of science biogerontology, geroscience or longevity research.
Credits
Stent animation CCBY BVM Medical https://commons.wikimedia.org/wiki/Fi...
Mice on a treadmill CCBY Aderbal Aguiar • Running mice in treadmill
Atherosclerosis progression diagram CCBY YitzhakNat https://commons.wikimedia.org/wiki/Fi...
Neutrophil diagram CC0 Mrmw https://commons.wikimedia.org/wiki/Fi...
And finally…
Follow me on Twitter / statto
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Like my page on Facebook / drandrewsteele
Follow me on Mastodon https://mas.to/@statto
Read my book, Ageless: The new science of getting older without getting old https://ageless.link/