Microbiome expands the genetic and functional capacity of its human host. Susan Lynch explains that human microbiome develops early in life and that gut microbes shape immune function and relate to disease outcomes in childhood. She also explores nextgeneration microbiome therapeutics and research. Recorded on 11/07/2019. [12/2019] [Show ID: 35240]

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0:00 Introduction
0:49 What We'll Cover Tonight.....
2:06 Microbes Predate Earth's Biodiversity
3:23 Culturebased Approaches do not Reflect the True Diversity or Physiology of Microorganisms
8:00 Enabling Tools to Interrogate Microbial Dark Matter
10:11 Humans are Superorganisms
11:12 The Gut Microbiome is Home to Several Trillion Microbes
12:22 Genetic Capacity of the Gut Microbiome Dwarfs that of the Human Host
13:48 The Gut Microbiome Evolves Over Human Lifespan
16:56 Human gut microbiome viewed across age and geography
19:07 Diet Rapidly and Reproducibly Alters the Gut Microbiome
21:52 Microbiome Perturbation Associates with Disease
22:38 The Gut Microbiome Influences Remote Organ and Immune Responses
23:47 Human Microbiome a Lever on Host Physiology
25:58 Yellow Soup for the Soul!
30:55 Asthma is Prevalent in Westernized Nations
36:47 Gut Microbiome Manipulation Alters Airway Mucosal Response to Allergen Challenge or Viral Infection
38:18 Gut Microbiome Manipulation Alters Serum Metabolic Response to Viral Respiratory Infection
41:05 Gut Microbiome Influences Hematopoietic Cell Programing via Plasmaassociated Mediators
42:52 How Could the Neonatal Gut Microbiome Influence Airway Disease Development in Childhood?
44:39 Highrisk for Asthma Gut Microbiota is Distinct at Birth and Exhibits Delayed Development in Infancy
46:13 Wayne County Health, Environment, Allergy & Asthma Longitudinal Study (WHEALS) Birth cohort
47:04 Neonatal Gut Microbiota State is Associated with Risk of Childhood Atopy and Asthma
49:49 Human Immune Cell Assay to Assess Neonatal Gut Microbiome Immunostimulatory Capacity
50:46 Highrisk Neonatal Gut Microbiome Induces Allergic Inflammation and Suppresses Tregulatory Cells
52:51 12,13 DIHOME Promotes Airway Allergic Sensitization and Increased Circulating IgE in Mice
54:09 Altered Linoleic Acid Metabolism Characterizes Highrisk Gut Microbiota
55:17 Is the Highrisk Neonatal Gut Microbiome Enriched for 12,13 DIHOME Production?
56:25 Neonatal Fecal 3EH Copy Number and 12,13 DIHOME Concentration Predicts Childhood Atopy and Asthma
57:33 Model for Childhood Atopic Asthma Development
59:40 Earlylife Gut Microbiota Relates to Childhood Obesity and Overweight Phenotypes at 2 Years