When Dr. Bill Harris began researching omega3 in the early 1980s, he was looking for an impact on cholesterol with what would be considered a high dose by today's standards: around 25 effective grams per day of omega3 from salmon. However, rather than finding an effect on cholesterol, they found a nearly 80% drop in triglycerides among patients with Fredrickson Type V hypertriglyceridemia.

While this dose is, no doubt, clinically excessive, the tolerability of even high doses used in the past provides context on just how hard it is to determine a true "tolerable upper intake level" when it comes to omega3. Listen for discussion of bleeding risk, omega6 to omega3 ratios, how the FDA set the recommended dose of prescription omega3, and more.

Watch the full interview here:
   • Dr. Bill Harris on the Omega3 Index:...  

CHAPTERS
00:00:00 25 grams per day
00:03:25 Is there a blood thinning effect?
00:09:06 Individuals need different amounts
00:09:58 Clinical trials (higher doses needed)
00:13:00 How the FDA determined 4g dose
00:13:50 Omega6 to omega3 ratio

Episode originally aired December 7th, 2021.