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Grey's Anatomy is an American medical drama television series that premiered on March 27, 2005, on the American Broadcasting Company (ABC) as a midseason replacement. The fictional series focuses on the lives of surgical interns, residents, and attendings as they develop into seasoned doctors while balancing personal and professional relationships. The title is an allusion to Gray's Anatomy, a classic human anatomy textbook first published in 1858 in London and written by Henry Gray.[1] Shonda Rhimes developed the pilot and continues to write for the series. She is also one of the executive producers alongside Betsy Beers, Mark Gordon, Krista Vernoff, Rob Corn, Mark Wilding, and Allan Heinberg, and recently, Ellen Pompeo. Although the series is set in Seattle, it is filmed primarily in Los Angeles, California.

The series revolves around the title character, Dr. Meredith Grey, played by Ellen Pompeo. Grey is first featured as an intern and later becomes the chief of general surgery, all the while exploring the ups and downs of a surgeon's life. The original cast consisted of nine starbilled actors: Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington, and Patrick Dempsey. The cast has undergone major changes throughout the series' run. At the start of the sixteenth season, the show had a large ensemble of fourteen actors—including four characters from the original cast (Meredith Grey, Alex Karev, Miranda Bailey and Richard Webber). Justin Chambers, who played Dr. Alex Karev, left the show during its sixteenth season.

Grey's Anatomy is the longestrunning scripted primetime show currently airing on ABC, and the longest scripted primetime series carried by ABC. As of February 28, 2019, it was the longestrunning American primetime medical drama series.[2] The series was most recently renewed for its seventeenth season. Its success catapulted longtime series regulars including Pompeo, Dempsey, and Oh to worldwide recognition; they were among the top five highestearning television actors in 2013.[3][4] While the show's ratings have fallen over the course of its run (it was once among the overall topten shows in the United States), it is still one of the highestrated shows among the 18–49 demographic, and the #3 drama on all of broadcast television in the United States.[5] The series was the highest revenueearning show on television in terms of advertising in the 2007–08 season; in 2017, it was ranked tenth on the list. In its fifteenth season, Grey's Anatomy ranked as ABC's highestrated drama.

Grey's Anatomy has been well received by critics throughout much of its run and has been included in various critics' yearend top 10 lists. Since its inception, the show has been described by the media outlets as a television "phenomenon" or a "juggernaut", owing to its longevity and dominant ratings. It is considered to have had a significant effect on popular culture and has received numerous awards, including the Golden Globe Award for Best Television Series – Drama and a total of thirtyeight Primetime Emmy Award nominations, including two for Outstanding Drama Series. The cast members have also received accolades for their individual performances.