Oprah Winfrey's primetime special on weight loss aimed to take the shame out of using prescription drugs to shed pounds. "An Oprah Special: Shame, Blame and the Weight Loss Revolution" featured some dramatic transformations, including a woman who says she lost 160 pounds in one year on Mounjaro. Winfrey is leading the way to taking the shame out of taking medication to lose weight. On “The View,” Whoopi Goldberg and Sunny Hostin said they used weight loss medication to shed pounds.