Paper link: https://www.mdpi.com/22181989/14/1/73
*Call to action*
HELP US promote this line of research by COPYING THE ABOVE LINK and including it in a post to social media, especially Twitter... I'll also be highlighting the best takes in the coming week ;)

0:00 – Intro
0:28 – metabolic demonstration
0:43 – Part I, the idea
1:30 – LMHR triad
1:58 – Lipid Energy Model
3:06 – Part II, the experimental design
4:19 – Part III, results
6:00 – results summary
6:40 – Part IV, What’s Next?
7:37 – Thanks and Call to Action


Aim: To tested the prediction consistent with the Lipid Energy Model (below) that adding carbohydrates (in the form of Oreo cookies) to an LMHR on a ketogenic diet would reduce LDLC levels by a similar, or greater, magnitude than highintensity statin therapy.

Findings: Oreo supplementation (12 cookies/d) lowered LDLC by 71% (273 mg/dl) in just 16 days. Rosuvastatin (20 mg/d) lowered LDLC by 32.5% (137 mg/dl). Thus, Oreos were ~2X as potent as highintensity statin therapy for LDL cholesterol lowering in this LMHR subject.

The Why: The LMHR phenotype has much to teach us about human metabolism, and cardiovascular disease pathophysiology. It's a new frontier that deserves further study, for the sake of the patients with this phenotype and for pure scientific curiosity! This experiment will serve as 'productive provocation,' a form of 'legitbait' that will hopefully help prompt discussions and largerscale experiments that need to happen.

6 select Prior publications
1/ META of RCTs (new, 1/16/24)
SotaMota A, FloresJurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS. Increased LDL cholesterol in adults with normal but not high body weight: a metaanalysis. Amer J of Clin Nutr. 2024; doi: 10.1016/j.ajcnut.2024.01.009
*LINK: https://www.sciencedirect.com/science...
VIDEO:    • NEW STUDY Proves it's BMI not Butter ...  

2/ n = 10 lean healthy women
Cooper ID, SanchezPizarro C, Norwitz NG, Feldman D, Kyriakidou Y, Edwards Kurtis, Petagine L, Eliiot BT, SotaMota A. Thyroid markers and body composition predict LDLcholesterol change in lean healthy women on a Ketogenic Diet: Experimental support for Lipid Energy Model. Frontiers in Endocrinology. 2023; doi: 10.3389/fendo.2023.1326768
LINK: https://www.frontiersin.org/articles/...
VIDEO:    • Cholesterol Manipulation in 10 Keto W...  

3/ JCL editorial
Norwitz NG, Mindrum M, Giral P, Kontush A, SotoMota A, Wood TR, D’Agostino DP, Manubolu VS, Budoff M, Krauss RM. Elevated LDL cholesterol among lean mass hyperresponders on lowcarbohydrate diets deserve urgent clinical attention and further research. Journal of Clinical Lipidology. 2022; doi:10.1016/j.jacl.2022.10.010
Link: https://www.lipidjournal.com/article/...

4/ Lipid Energy Model
Norwitz NG, SotoMota A, Kaplan R, Ludwig DS, Budoff M, Kontush A, Feldman D. The Lipid Energy Model: reimagining lipoprotein function in the context of carbohydraterestricted diets. Metabolites. 2022; doi: 10.3390/metabo12050460
Link: https://pubmed.ncbi.nlm.nih.gov/35629...
Video:    • High LDL Cholesterol Increases on a L...  

5/ LMHR, first paper
Norwitz NG, Feldman D, SotoMota A, Kalayjian T, Ludwig DS. Elevated LDLcholesterol with a carbohydraterestricted diet: evidence for a “lean mass hyperresponder” phenotype. Current Developments in Nutrition. 2022; doi: 10.1093/cdn/nzab144
Link: https://cdn.nutrition.org/article/S24...

6/ Low Sat Fat LMHR case report
Norwitz NG, SotoMota A, Feldman D, Parpos S, Budoff M. Case report: hypercholesterolemia “lean mass hyperresponder” phenotype presents in the context of a low saturated fat carbohydrate restricted diet. Frontiers in Endocrinology. 2022; doi: 10.3389/fendo.2022.830325
Link: https://www.ncbi.nlm.nih.gov/pmc/arti...
Video:    • New Case Study  High LDL Cholesterol...