The TLC reality show My 600lb Life has seen many inspiring and heartwarming transformations over the years, but not every story has been a success. Dr. Younan Nowzaradan always informs the patients about all of the risks up front, and some have sadly died while attempting to shed the pounds, while others have not been able to go through the program and have stepped away. From the man who managed to lose 350 pounds but still struggled with addiction to the brothers who had a difficult time on the show, here are some stories from My 600lb Life that ended in tragedy.

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It's a risky business | 0:00
Robert Buchel | 1:19
The Assanti brothers | 2:33
Sean Milliken | 3:42
Penny Saeger | 4:41
Kelly Mason | 5:44
James King | 6:53
Schenee Murry | 8:06
Henry Foots | 8:57
Mercedes Cephas | 9:34
Lisa Fleming | 10:16
Jeanne Covey | 11:12
James "LB" Bonner | 11:55

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