TOPIC: Metamorphosis in Amphibians(Part2) || Thyroid Hormone Signaling || Developmental Biology || CSIR NET 2024

Amphibian metamorphosis is associated with morphological changes that prepare an aquatic organism for a primarily terrestrial existence.
In urodeles (salamanders), these changes include the resorption of the tail fin, the destruction of the external gills, and a change in skin structure.
In anurans (frogs and toads), the changes are more dramatic, with almost every organ subject to modification.
The changes in amphibian metamorphosis are initiated by thyroid hormones such as thyroxine (T4) and triiodothyronine (T3) that travel through the blood to reach all the organs of the larva.
When the larval organs encounter these thyroid hormones, they can respond in any of four ways:
Growth (as in the hindlimbs of the frog),
Death (as in the tail of the frog),
Remodeling (as in the frog’s intestine), and
Respecification (as in the liver enzymes of the frog).
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Metamorphosis in Amphibians
Thyroid Hormone Role in metamorphosis
metamorphosis in frog
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