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How does sleep help us remember things better?
In this video we will explore the wonders of the hippocampus a brain region involved in memory consolidation and spatial navigation. We will talk about the phenomenon of hippocampal replay and the Sharp Wave Ripples.

My name is Artem, I'm a computational neuroscience student and researcher at Moscow State University.
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OUTLINE:
00:00 Introduction
01:01 Sponsor message
02:23 Cortex and Hippocampus
04:52 Sharp Wave Ripple
06:45 Fastreverse memory replay
08:55 Fastforward replay
10:03 Conclusion and Outlook

REFERENCES:
1.Ólafsdóttir, H. F., Bush, D. & Barry, C. The Role of Hippocampal Replay in Memory and Planning. Current Biology 28, R37–R50 (2018).
2.Hannah R. Joo & Loren M. Frank. The hippocampal sharp waveripple in memory retrieval for immediate use and consolidation. Nature Reviews Neuroscience (2018) doi:10.1038/s4158301800771.
3.Buzsáki, G. The brain from inside out. (Oxford University Press, 2019).
4.Roux, L., Hu, B., Eichler, R., Stark, E. & Buzsáki, G. Sharp wave ripples during learning stabilize the hippocampal spatial map. Nat Neurosci 20, 845–853 (2017).
5.Girardeau, G., Benchenane, K., Wiener, S. I., Buzsáki, G. & Zugaro, M. B. Selective suppression of hippocampal ripples impairs spatial memory. Nat Neurosci 12, 1222–1223 (2009).
6.Feld, G. B. & Born, J. Sculpting memory during sleep: concurrent consolidation and forgetting. Current Opinion in Neurobiology 44, 20–27 (2017).
7.Ambrose, R. E., Pfeiffer, B. E. & Foster, D. J. Reverse Replay of Hippocampal Place Cells Is Uniquely Modulated by Changing Reward. Neuron 91, 1124–1136 (2016).
8.Marcelo G. Mattar & Nathaniel D. Daw. Prioritized memory access explains planning and hippocampal replay. Nature Neuroscience (2018) doi:10.1038/s415930180232z.
9.Jens G. Klinzing, Niels Niethard, & Jan Born. Mechanisms of systems memory consolidation during sleep. Nature Neuroscience (2019) doi:10.1038/s4159301904673.
10.Penelope A. Lewis & Daniel Bendor. How Targeted Memory Reactivation Promotes the Selective Strengthening of Memories in Sleep. Current Biology (2019) doi:10.1016/j.cub.2019.08.019.
11.Wenbo Tang, Justin D. Shin, Loren M. Frank, & Shantanu P. Jadhav. HippocampalPrefrontal Reactivation during Learning Is Stronger in Awake Compared with Sleep States. The Journal of Neuroscience (2017) doi:10.1523/jneurosci.229117.2017.
12.Buzsáki, G. Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning. Hippocampus 25, 1073–1188 (2015).
13.Diba, K. & Buzsáki, G. Forward and reverse hippocampal placecell sequences during ripples. Nat Neurosci 10, 1241–1242 (2007).
14.Shin, J. D., Tang, W. & Jadhav, S. P. Dynamics of Awake HippocampalPrefrontal Replay for Spatial Learning and MemoryGuided Decision Making. Neuron 104, 11101125.e7 (2019).
15.Mehta, M. R. Corticohippocampal interaction during updown states and memory consolidation. Nat Neurosci 10, 13–15 (2007).
16.Aussel, A., Buhry, L., Tyvaert, L. & Ranta, R. A detailed anatomical and mathematical model of the hippocampal formation for the generation of sharpwave ripples and thetanested gamma oscillations. J Comput Neurosci 45, 207–221 (2018).


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This video was sponsored by Brilliant