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How to Not Die | David Sinclair | Knowledge Project 136

The Knowledge Project

Biologist and genetics expert Dr. David Sinclair is out to prove he can live past 100 years old, and he thinks you can too. On this episode Sinclair goes indepth on the process of aging and the techniques you can incorporate into your life that help you live a longer, healthier life, including optimizing your diet, the benefits of exercise, the role of a positive attitude, the importance of sleep, the three supplements he takes every day, why it’s never too late to slow the process of aging, and so much more.

Dr. Sinclair is a professor of genetics and codirector of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, and he is best known for his research on aging, with a focus on epigenetics. He’s been called one of the 100 Most Influential People in the World by Time, and in 2019 he released the New York Times bestselling book, Lifespan: Why We Age – and Why We Don't Have To.

00:00 Intro
01:24 What is aging?
02:52 What happens in our body during aging?
06:10 How fasting decreases aging
15:00 On eating three meals a day
18:39 The best things to eat to reduce aging
23:05 Organic v nonorganic foods
27:04 Should we only eat food that's "in season?"
29:46 On sugar
31:42 How to test your biological age
33:22 Using exercise effectively
36:18 Sleep and aging
40:36 The benefits of saunas and hot tubs
45:04 The relationship between stress and aging
47:55 How positive attitude impacts lifespan
48:34 NMN, Athletic Greens, and resveratrol
52:57 Why David quit dairy (and did it matter?)
58:00 When should you start slowing your aging process?
01:01:05 On puberty and aging
01:02:53 Are biological problems becoming engineering problems?
01:08:54 Using drugs to reverse aging
01:11:24 On lyme disease
01:17:06 On hipreplacement and increased death rates
01:21:36 How to think about aging before it's too late
01:23:30 What's the ultimate age we can live?
01:28:30 Secondorder effects of living longer


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Like the mentor you’ve always dreamed of having, The Knowledge Project shares timely yet timeless lessons for work and life. Past guests include Naval Ravikant, Daniel Kahneman, Jim Collins, Angela Duckworth, Seth Godin, Melanie Mitchell, & Esther Perel.

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