Edema (swelling of the legs, ankles, feet) is a very common condition. It is a sign that things are not right in the body, and many medications can cause this worrisome symptom. This video lists the 11 medications that cause leg swelling.

Sometimes you need to take a medicine. Keep in mind that there is almost always another medication choice if you have edema caused by your current one. If you are taking one of these 11 medicines that cause edema, talk with your doctor about changing to another.

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Medications discussed: Pramipexole,
Clonidine,
Trazadone,
MAOInhibitors (Isocarboxazid (Marplan), Phenelzine (Nardil), Selegiline (Emsam), Tranylcypromine (Parnate), selegiline (Eldepryl, Zelapar, EMSAM) and rasagiline (Azilect)),
NSAID's (ibuprofen, naproxen, diclofenac, and celecoxib, Ibuprofen, naproxen),
CCB's (amlodipine (Norvasc), amlodipine + atorvastatin (Caduet), amlodipine + benazepril (Lotrel), amlodipine + valsartan (Exforge), amlodipine + telmisartan (Twynsta), amlodipine + olmesartan (Azor), amlodipine + olmesartan + hydroclorothiazide (Tribenzor), amlodipine + aliskiren + hydroclorothiazide, amlodipine + perindopril (Prestalia), clevidipine (Cleviprex), diltiazem (Cardizem), felodipine (Cardene, Cardene SR), isradipine, nicardipine, nimodipine, nisoldipine (Sular), verapamil (Calan))
betaBlockers acebutolol (Sectral), atenolol (Tenormin), betaxolol (Kerlone), bisoprolol fumarate (Zebeta), carvedilol (Coreg), esmolol (Brevibloc)
labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), nebivolol (Bystolic), penbutolol (Levatol), propranolol (Hemangeol, Inderal LA, Inderal XL, InnoPran XL), sotalol (Betapace, Sorine)
Corticosteroids bethamethasone, (Celestone), prednisone (Prednisone), prednisolone (Orapred, Prelone), triamcinolone (Kenalog), methylprednisolone (Medrol, DepoMedrol, SoluMedrol), dexamethasone (Dexamethasone Intensol, DexPak 10 Day, DexPak)
gabapentin (Neurontin), pregabalin (Lyrica)
pioglitazone (Actos), rosiglitazone (Avandia)
Insulin (many brands)

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Ken D Berry, MD, is a Family Physician with 20 years of clinical practice.
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