Sooner or later every comic has to deal with some opinionated audience member. Generally these hecklers are awful because they mess up timing and pacing for the comic, and tend to throw the entire show off balance, therefore ruining the show for all other paying customers.
SOMETIMES though, hecklers add a great new element to live comedy. Given that the person they're ripping on makes fun of shit for a living, there's always a good chance that heckler will get thoroughly owned.
With that, here are great instances in which hecklers were properly put in their place.

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FEATURED COMEDIANS:
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Greg Proops
Greg Proops has not only done voiceover work for Star Wars movies, but he also
voiced the title character of the American version of
the animated children's show Bob the Builder.

Bill Burr
During a show in 2014, Bill Burr was telling a story about going to
a club when he was interrupted by an audience member yelling out
that he can’t go to clubs because he's blind.

Jim Jefferies
During an interview on the Opie and Anthony Show, Jim Jefferies
revealed that he has Bananaphobia, a very rare condition that
forced him to leave the room in panic when Opie ate a banana and taunted
Jefferies by waving it in front of him.

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Copyright Disclaimer under section 107 of the Copyright Act 1976, allowance is made for “fair use” for purposes such as criticism, comment, news reporting, teaching, scholarship, education and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Educational use tips the balance in favor of fair use.

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FEATURED COMICS:
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Bo Burnham
Bill Burr
Jim Jefferies
Joe Rogan
Richard Pryor

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MUSIC:
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...Will update soon