To understand the answer to this question you must understand how efficacy data is presented and what gets published in medical journals. Most of the data that gets published is overwhelmingly positive. Very few if any negative trials are published and in 2008 Turner and colleagues brought this to our attention in the New England Journal of Medicine (NEJM). What they discovered was the FDA data base had an even split 50% negative and 50% positive studies when it came to antidepressants

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