Maria Uloko, MD, discusses symptoms, causes, and treatments for postfinasteride syndrome (PFS) and postSSRI sexual dysfunction (PSSD) in men. She explains the controversy behind the PFS diagnosis and discusses the attention it has gathered in urology, citing the NIH’s inclusion of PFS in its 2015 list of Rare and Genetic Diseases. Dr. Uloko also explores various SSRIs and how increased serotonin activity can lead to PSSD. She ultimately recommends a biopsychosocial approach for both conditions and strongly advocates for patient validation during treatment.