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► THIS VIDEO will provide an insightful exploration into the complexities of chronic kidney disease (CKD), focusing on its most common causes. It's a mustwatch for medical students eager to understand the multifaceted nature of CKD, as the lecturer meticulously subdivides the conditions based on the affected parts of the nephron, including the tubules, interstitium, vascular component, glomerular component, and postrenal aspects.

We start with an indepth look at tubules and interstitiumrelated diseases. Here, polycystic kidney disease takes center stage, recognized as the most prevalent genetic disease among adults. This segment delves into its autosomal dominant nature, associated PKD1 and PKD2 mutations, and how these mutations affect epithelial cell cilia. Also discussed are the disease's progression towards renal replacement therapy and current treatment limitations. Pediatric nephrology is highlighted too, emphasizing the autosomal recessive variant that presents in childhood, often leading to kidney and liver transplants. ‍⚕

Furthermore, the video addresses autoimmune diseases affecting the tubuleinterstitial region, such as Sjogren's syndrome and sarcoidosis. Sjogren's is presented with its hallmark features destruction of lacrimal and salivary glands and sarcoidosis, defined by noncaseating granulomas. Both conditions are linked to distinct inflammatory infiltrates, crucial for understanding their impacts on kidney function.

The vascular compartment of the kidney is another critical area covered. Hypertensive vasculopathy and hypertensive nephrosclerosis, common causes of dialysis in the United States, are thoroughly examined. In addition, renal atheroembolic disease is described, underscoring its role in acute kidney injury and progression to chronic disease.

Lastly, the postrenal aspects of CKD are discussed, highlighting conditions like benign prostatic hyperplasia, urethral strictures, and nephrolithiasis. The impact of prolonged urinary obstruction and its consequences on kidney parenchyma are thoroughly analyzed, providing a comprehensive understanding of these conditions.

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Disclaimer: Lecturio offers educational content for healthcare students to prepare for exams and/or to review knowledge gained at a Medical School. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment suggestions. Our resources are strictly for educational purposes. Always consult healthcare professionals for medical concerns.

► THE PROF ‍
Dr. Sussman is an Associate Professor of Medicine at the University of Arizona Health Sciences Center. She completed her medical schooling at the University of Arizona and her Internal Medicine/Chief Residency training at the University of Washington. She subsequently pursued a Nephrology Clinical and Research Fellowship at the University of Washington. Dr. Sussman was recruited back to the University of Arizona in 2009 and has served as a clinician educator with a strong emphasis in medical student education. Dr. Sussman maintains an active interest in Glomerulonephritis and innovative teaching methodologies in medical education. She additionally serves as the Medical Director of Sahaurita DCI Desert Dialysis unit and has developed and is the Clinical Director of the nocturnal incenter dialysis program at DCI South Tucson.

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Chapters:
00:00 Introduction to Chronic Kidney Disease Causes
00:30 Polycystic Kidney Disease
02:00 Autoimmune Diseases
03:10 Reflux Nephropathy
04:02 Hypertensive Vasculopathy
04:32 Renovascular Disease
05:08 Renal Atheroembolic Disease
05:43 Diabetic Nephropathy
06:25 Primary Glomerular Disease
06:38 PostRenal Causes
07:32 Study Smarter with Lecturio