Some cities in the United States that are considered the most expensive to live in include San Francisco, New York City, Honolulu, Los Angeles, and Boston. The main factors contributing to the high cost of living in these cities are the high cost of living in the desired area, and the high cost of living in general such as transportation, food, and entertainment. This video discusses the cities with the highest costs of living in America and the reasons why they are considered expensive cities to live in.