Leptin resistance is probably the single most important factor when you determine how likely you are to lose weight. It's more important than any other hormone as it pertains to your ability to lose weight (and why you gain weight).

When your leptin levels become too high your body can become resistant to your own leptin and you are said to be in a state of leptin resistance.

This is a HUGE problem for many people. In fact, I believe that everyone who is overweight has some degree of leptin resistance and it's more important than other hormone imbalances such as insulin resistance.

Understanding what stage of leptin resistance you have helps to determine how easy it will be for you to lose weight and how long it will take to get to your target goal.

You can assess your stage of leptin resistance by checking your serum leptin level. You will want to check your serum leptin level in the FASTED state.

Once you have your result you can then determine your stage by looking at the stages below:

Stage 1 (mild leptin resistance): serum leptin between 1019 ng/ml.

At this stage, you should be able to use diet, exercise, and supplements.

Stage 2 (moderate leptin resistance): serum leptin between 2029 ng/ml.

At this stage, you will need to use diet/exercise, leptin supplements, and leptin medications.

Stage 3 (severe leptin resistance): serum leptin greater than 30 ng/ml.

At this stage you will need to use ALL of the therapies above and use 23 medications for leptin resistance.

The following risk factors help to determine how likely you are to become leptin resistance (the more of these you have the more likely you are to have severe leptin resistance):

A history of yoyo dieting.
Your current weight (the more you weigh the more leptin resistance you will have)
Your age (worse if you are over the age of 50)
Your hormone balance (those in menopause and those with thyroid conditions have higher leptin levels)
Inflammation (the more inflammation in your body the harder it will be to lose weight)
Genetics (some people will just be more susceptible to leptin resistance)
The presence of insulin resistance (if present your leptin will be higher)

Leptin supplements include:
glycosaminoglycans
high dose fish oil
high dose Lglutamine

Leptin medications include:
Calcitonin
GLP1 agonists
SGLT2 inhibitors
Naltrexone
Wellbutrin

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Disclaimer:
Dr. Westin Childs received his Doctor of Osteopathic Medicine from Rocky Vista University College of Osteopathic medicine in 2013. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Childs is no longer practicing medicine and does not hold an active medical license so he can focus on helping people through videos, blog posts, research, and supplement formulation. To read more about why he is no longer licensed please see this page: https://www.restartmed.com/whathappe...

This video is for general informational, educational, and entertainment purposes only. It should not be used to selfdiagnose and it is not a substitute for a medical exam, treatment, diagnosis, prescription, or recommendation. It does not create a doctorpatient relationship between Dr. Childs and you. You should not make any changes to your medications or health regimens without first consulting a physician. If you have any questions please consult with your current primary care provider. Restart Medical LLC and Dr. Westin Childs are not liable or responsible for any advice, course of treatment, diagnosis, or any other information, services, or product you obtain through this website or video.
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